Nasatapp Cough Drug Interactions

Dextromethorphan HBr: Patients on monoamine oxidase (MAO) inhibitors (e.g., tricyclic antidepressants) should not use products containing dextromethorphan without the supervision of a physician. Dextromethorphan has a tendency to inhibit the metabolism of and thus potentiate the effects of certain MAO inhibitors.
Phenylephrine HCI: Do not use the product together with sympathomimetic agents (e.g., Epinephrine, etc.) and general anesthetics (e.g., Halothane, etc.) because of the possibility for increased toxicity. Concurrent administration with medicines for depression (e.g., Amitriptyline, Imipramine, Sertraline, Moclobemide, etc.) may result in hypertensive crisis (sudden, severe increase in blood pressure that can lead to stroke). Taking an adrenergic-blocking agent (e.g., Phenothiazine drugs, Phentolamine, Propranolol, etc.) before the administration of the product may decrease the effect of phenylephrine. Tell the doctor about other medicines the child is taking, especially other medicines for cough, cold, or allergy.
Paracetamol: Paracetamol in therapeutic doses produces only slight increases in the hypoprothrombinemic response to Warfarin or Coumadin.
Concomitant use of Paracetamol and Phenothiazine may possibly cause severe hypothermia.
Concomitant administration with Isoniazid may result in an increased risk of hepatotoxicity.
Anticonvulsants (e.g., Phenytoin, barbiturates, carbamazepine) that induce hepatic microsomal enzymes may increase Paracetamol-induced liver toxicity because of increased conversion of the drug to hepatic metabolites.